Sphere forming method and apparatus

A system is provided for forming small accurately spherical objects. Preformed largely spherical objects are supported at the opening of a conduit on the update of hot gas emitted from the opening, so the object is in a molten state. The conduit is suddenly jerked away at a downward incline, to allow the molten object to drop in free fall, so that surface tension forms a precise sphere. The conduit portion that has the opening, lies in a moderate vacuum chamber, and the falling sphere passes through the chamber and through a briefly opened valve into a tall drop tower that contains a lower pressure, to allow the sphere to cool without deformation caused by falling through air

Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy

High-frequency cortical activity, particularly in the 250–600 Hz (fast ripple) band, has been implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are highly specific for the seizure initiation zone. However, evidence for the association of fast ripples with epileptic foci depends on animal models and human cases with substantial lesions in the form of hippocampal sclerosis, which suggests that neuronal loss may be required for fast ripples. In the present work, we tested whether cell loss is a necessary prerequisite for the generation of fast ripples, using a non-lesional model of temporal lobe epilepsy that lacks hippocampal sclerosis. The model is induced by unilateral intrahippocampal injection of tetanus toxin. Recordings from the hippocampi of freely-moving epileptic rats revealed high-frequency activity (4100 Hz), including fast ripples. High-frequency activity was present both during interictal discharges and seizure onset. Interictal fast ripples proved a significantly more reliable marker of the primary epileptogenic zone than the presence of either interictal discharges or ripples (100–250 Hz). These results suggest that fast ripple activity should be considered for its potential value in the pre-surgical workup of non-lesional temporal lobe epilepsy

Valorisation of macroalgae via the integration of hydrothermal carbonisation and anaerobic digestion

This study investigates the integration of hydrothermal carbonisation (HTC) with anaerobic digestion (AD) as a valorisation route for two macroalgae species; S. latissima (SL) and F. serratus (FS). HTC reactions were conducted at temperatures of 150°C, 200°C and 250°C, with resulting hydrochars, process waters and hydrothermal slurries assessed for biomethane potential yields. Un-treated SL generated similar biomethane levels compared to all SL slurries. Whereas all FS slurries improved biomethane yields compared to un-treated FS. Hydrochars represent a greater energy carrier if used as a solid fuel, rather than a feedstock for anaerobic digestion. Integrating HTC and AD, through hydrochar combustion and process water digestion has a greater energetic output than anaerobic digestion of the un-treated macroalgae. Treatment at 150°C, with separate utilisation of products, can improve the energetic output of S. latissima and F. serratus by 47 % and 172 % respectively, compared to digestion of the un-treated macroalgae

The MGDO software library for data analysis in Ge neutrinoless double-beta decay experiments

The GERDA and Majorana experiments will search for neutrinoless double-beta decay of germanium-76 using isotopically enriched high-purity germanium detectors. Although the experiments differ in conceptual design, they share many aspects in common, and in particular will employ similar data analysis techniques. The collaborations are jointly developing a C++ software library, MGDO, which contains a set of data objects and interfaces to encapsulate, store and manage physical quantities of interest, such as waveforms and high-purity germanium detector geometries. These data objects define a common format for persistent data, whether it is generated by Monte Carlo simulations or an experimental apparatus, to reduce code duplication and to ease the exchange of information between detector systems. MGDO also includes general-purpose analysis tools that can be used for the processing of measured or simulated digital signals. The MGDO design is based on the Object-Oriented programming paradigm and is very flexible, allowing for easy extension and customization of the components. The tools provided by the MGDO libraries are used by both GERDA and Majorana.Comment: 4 pages, 1 figure, proceedings for TAUP201

A multitude of fears coupled with excitement – children’s nursing students feelings prior to their first practice placement

Introduction: The first practice placement is of upmost importance for nursing students, causing considerable anxiety (Brien, 2012) and is part-way attributed to an increased risk of attrition during and after this experience (Melling, 2011). Providing students with adequate preparation for and support during placement is central to their learning and development, thus ensuring that they are fit for professional practice and registration at qualification (NMC, 2010). Aims: Taken from a study examining preparation for and support during the first practice placement as children’s nursing students, from the perspective of both students and professionals, this paper highlights the anxieties experienced by students and the strategies which helped prepare and support them during their introduction to nursing practice. Methods: Data were collected by a specifically designed self-administered questionnaire from 21 children’s nursing students prior to their first placement. A focus group was held with 5 students following the placement and used the Nominal Group technique to build consensus around what helped prepare them for practice and made suggestions for future preparation. Results: The questionnaire suggested that most students, although looking forward to their first clinical experience, were anxious to appear interested and helpful. Fitting in and getting on with their mentor(s) was also of concern. They were also fearful of making mistakes and keen to demonstrate their professionalism, despite being novices. The focus group highlighted that, of the activities provided by the university educators, meeting a senior student was the most helpful, followed by making pre-placement visits, telephone calls, peer support and the placement website. During the placement the relationship with their mentor(s) and other staff were highly valued. Discussion/Implications/Conclusions: Whilst the students had worries prior to placement, the preparation provided by both the hosting trust and the academic institution helped buffer the anxiety experienced, alongside a welcoming mentor. If the mentor was not particularly friendly the student attached themselves to someone who they perceived to be more helpful, in some cases that person being a third year student. Peer support and sharing of knowledge was therefore crucial and involving a senior student in a preparation for practice session is a clear recommendation. References: Brien, S (2012) Beyond Competence – Literature Review Final Report. Southampton University: HEA. Melling, S. (2011) Transition: an exploration of student nurse experience in their first practice placement. Unpublished D.Ed. thesis. University of Nottingham. Nursing and Midwifery Council (2010) Standards for Pre-Registration Nursing Education. London: NMC

Rapid bidirectional reorganization of cortical microcircuits.

Mature neocortex adapts to altered sensory input by changing neural activity in cortical circuits. The underlying cellular mechanisms remain unclear. We used blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to show reorganization in somatosensory cortex elicited by altered whisker sensory input. We found that there was rapid expansion followed by retraction of whisker cortical maps. The cellular basis for the reorganization in primary somatosensory cortex was investigated with paired electrophysiological recordings in the periphery of the expanded whisker representation. During map expansion, the chance of finding a monosynaptic connection between pairs of pyramidal neurons increased 3-fold. Despite the rapid increase in local excitatory connectivity, the average strength and synaptic dynamics did not change, which suggests that new excitatory connections rapidly acquire the properties of established excitatory connections. During map retraction, entire excitatory connections between pyramidal neurons were lost. In contrast, connectivity between pyramidal neurons and fast spiking interneurons was unchanged. Hence, the changes in local excitatory connectivity did not occur in all circuits involving pyramidal neurons. Our data show that pyramidal neurons are recruited to and eliminated from local excitatory networks over days. These findings suggest that the local excitatory connectome is dynamic in mature neocortex

A scoping review of ontologies related to human behaviour change.

Ontologies are classification systems specifying entities, definitions and inter-relationships for a given domain, with the potential to advance knowledge about human behaviour change. A scoping review was conducted to: (1) identify what ontologies exist related to human behaviour change, (2) describe the methods used to develop these ontologies and (3) assess the quality of identified ontologies. Using a systematic search, 2,303 papers were identified. Fifteen ontologies met the eligibility criteria for inclusion, developed in areas such as cognition, mental disease and emotions. Methods used for developing the ontologies were expert consultation, data-driven techniques and reuse of terms from existing taxonomies, terminologies and ontologies. Best practices used in ontology development and maintenance were documented. The review did not identify any ontologies representing the breadth and detail of human behaviour change. This suggests that advancing behavioural science would benefit from the development of a behaviour change intervention ontology.Wellcome Trus

Clinical assessment of hand oedema: A systematic review

Introduction: Assessment of oedema after trauma or surgery is important to determine whether treatment is effective and to detect change over time. Volumetry is referred to as the ‘gold standard’ method of measuring volume. However, this has practical limitations and other methods are available. The aim of this systematic review was to evaluate the psychometric properties of alternative methods used to assess hand oedema. Methods: A search of electronic bibliographic databases was undertaken for any studies published in English reporting the psychometric evaluation of a method for measuring hand oedema, in an adult population with hand swelling from surgery, trauma or stroke. The Consensus‐based Standards for the Selection of health Measurement Instruments (COSMIN) checklist was used to evaluate the methodological quality. Results: Six studies met the inclusion criteria. Three methods were identified assessing hand oedema: perometry, visual inspection and the figure-of-eight tape measure, all were compared to volumetry. Four different psychometric properties were assessed. Studies scored fair or poor on COSMIN criteria. There is low-quality evidence supporting the use of the figure-of-eight tape measure to assess hand volume. The perometer systematically overestimated volume and visual estimation had poor sensitivity and specificity. Discussion: The figure-of-eight tape measure is the best alternative to volumetry for hand oedema. Benefits include reduced cost and time while having comparable reliability to the ‘gold standard’. Further research is needed to compare methods in patients with greater variability of conditions and with isolated digit oedema. Visual estimation of hand oedema is not recommended